MLN8054 SECRETS

Table 1 summarizes the noticed DLTs by cohort. Somnolence, which resolved in all but just one patient, was the one DLT for MLN8054 offered devoid of methylphenidate or modafinil. The onset of somnolence and its severity usually were being correlated with dose and Cmax. Mainly because somnolence was considered linked to Cmax, the dosing schedule was